Adult Mesenchymal Stem Cells Derived from Embryonic Stem Cells
نویسنده
چکیده
Mesenchymal stem cells (MSC) are useful in cell therapy and stem cell research but they have a limited lifespan in culture. Our goal was to develop a unique and limitless supply of mesenchymal stem cells derived from human embryonic stem cells, opening up new uses and enhance existing uses of these important cell types. For any application that uses large quantities of MSC, such as high throughput drug compound screening, eventually MSC will have to be rederived, likely from a different genetic background, thus assay responses may differ among genetic backgrounds and could reduce assay consistency and robustness. Using the NIH approved cell lines BG01 and WA09, respectively, we have developed a method for the derivation of MSC-like cell lines that can differentiate into mesenchymal lineages such as bone and cartilage. The cells will be of use by researchers developing human and veterinary applications in cell therapy
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